Biochemical aspects of magnesium-enhanced bone regeneration

Current research is focused on practical implications of magnesium-based implants largely due to their biodegradability and ability promote bone healing formation. However, the mechanism underlying osteogenesis regulation by magnesium still unclear. We describe cellular molecular mechanisms effect ions (Mg2+) growth following device implantation. The presented data demonstrate magnesium-induced activation canonical Wnt/β-catenin signaling pathway in human marrow stromal cells resulting differentiation into osteoblasts, osteogenic recovery defects. role responsible for osteopromotive properties Mg2+ associated with unique transient receptor potential melastatin 7 (TRPM7) cation channels mediating influx. TRPM7-mediated influx important platelet-derived factor (PDGF)-induced proliferation, adhesion, migration as well promotion Mg2+-associated regeneration. discuss intracellular processes, expression vascular endothelial (VEGF), hypoxia-inducible factor-2α, peroxisome proliferator-activated receptor-γ coactivator 1α. can regeneration enhancing production type X collagen VEGF marrow.